Bone–titanium oxide interface in humans revealed by transmission electron microscopy and electron tomography
Identifieur interne : 004283 ( Main/Exploration ); précédent : 004282; suivant : 004284Bone–titanium oxide interface in humans revealed by transmission electron microscopy and electron tomography
Auteurs : Anders Palmquist [Suède] ; Kathryn Grandfield [Suède] ; Birgitta Norlindh [Suède] ; Torsten Mattsson [Suède] ; Rickard Br Nemark [Suède] ; Peter Thomsen [Suède]Source :
- Journal of the Royal Society Interface [ 1742-5689 ] ; 2011.
Descripteurs français
- KwdFr :
- MESH :
- Wicri :
- geographic : Suède.
English descriptors
- KwdEn :
- MESH :
- chemical : Dental Implants, Titanium.
- geographic : Sweden.
- surgery : Jaw, Edentulous.
- ultrastructure : Bone and Bones.
- Aged, Electron Microscope Tomography, Humans, Male, Microscopy, Electron, Transmission, Osseointegration, Surface Properties.
Abstract
Osseointegration, the direct contact between an implant surface and bone tissue, plays a critical role in interfacial stability and implant success. Analysis of interfacial zones at the micro- and nano-levels is essential to determine the extent of osseointegration. In this paper, a series of state-of-the-art microscopy techniques are used on laser-modified implants retrieved from humans. Partially laser-modified implants were retrieved after two and a half months' healing and processed for light and electron microscopy. Light microscopy showed osseointegration, with bone tissue growing both towards and away from the implant surface. Transmission electron microscopy revealed an intimate contact between mineralized bone and the laser-modified surface, including bone growth into the nano-structured oxide. This novel observation was verified by three-dimensional Z-contrast electron tomography, enabling visualization of an apatite layer, with different crystal direction compared with the apatite in the bone tissue, encompassing the nano-structured oxide. In conclusion, the present study demonstrates the nano-scale osseointegration and bonding between apatite and surface-textured titanium oxide. These observations provide novel data in human specimens on the ultrastructure of the titanium–bone interface.
Url:
DOI: 10.1098/rsif.2011.0420
PubMed: 21849383
PubMed Central: 3243398
Affiliations:
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and electron tomography</title><author><name sortKey="Palmquist, Anders" sort="Palmquist, Anders" uniqKey="Palmquist A" first="Anders" last="Palmquist">Anders Palmquist</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Biomaterials</addr-line>,<institution>Sahlgrenska Academy at University of Gothenburg</institution>,<addr-line>Göteborg</addr-line>,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Grandfield, Kathryn" sort="Grandfield, Kathryn" uniqKey="Grandfield K" first="Kathryn" last="Grandfield">Kathryn Grandfield</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Department of Applied Materials Science</addr-line>,<institution>Ångström Laboratory, Uppsala University</institution>,<addr-line>Uppsala</addr-line>,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Norlindh, Birgitta" sort="Norlindh, Birgitta" uniqKey="Norlindh B" first="Birgitta" last="Norlindh">Birgitta Norlindh</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Biomaterials</addr-line>,<institution>Sahlgrenska Academy at University of Gothenburg</institution>,<addr-line>Göteborg</addr-line>,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mattsson, Torsten" sort="Mattsson, Torsten" uniqKey="Mattsson T" first="Torsten" last="Mattsson">Torsten Mattsson</name><affiliation wicri:level="1"><nlm:aff id="af3"><institution>Uppsala Oral and Maxillofacial Centre</institution>,<addr-line>Uppsala</addr-line>,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Br Nemark, Rickard" sort="Br Nemark, Rickard" uniqKey="Br Nemark R" first="Rickard" last="Br Nemark">Rickard Br Nemark</name><affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Orthopaedics</addr-line>,<institution>Sahlgrenska University Hospital</institution>,<addr-line>Göteborg</addr-line>,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thomsen, Peter" sort="Thomsen, Peter" uniqKey="Thomsen P" first="Peter" last="Thomsen">Peter Thomsen</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Biomaterials</addr-line>,<institution>Sahlgrenska Academy at University of Gothenburg</institution>,<addr-line>Göteborg</addr-line>,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of the Royal Society Interface</title><idno type="ISSN">1742-5689</idno><idno type="eISSN">1742-5662</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Bone and Bones (ultrastructure)</term><term>Dental Implants</term><term>Electron Microscope Tomography</term><term>Humans</term><term>Jaw, Edentulous (surgery)</term><term>Male</term><term>Microscopy, Electron, Transmission</term><term>Osseointegration</term><term>Surface Properties</term><term>Sweden</term><term>Titanium</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Humains</term><term>Implants dentaires</term><term>Microscopie électronique à transmission</term><term>Mâchoire édentée ()</term><term>Mâle</term><term>Os et tissu osseux (ultrastructure)</term><term>Ostéo-intégration</term><term>Propriétés de surface</term><term>Sujet âgé</term><term>Suède</term><term>Titane</term><term>Tomographie en microscopie électronique</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Dental Implants</term><term>Titanium</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Sweden</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Jaw, Edentulous</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Bone and Bones</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Electron Microscope Tomography</term><term>Humans</term><term>Male</term><term>Microscopy, Electron, Transmission</term><term>Osseointegration</term><term>Surface Properties</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Implants dentaires</term><term>Microscopie électronique à transmission</term><term>Mâchoire édentée</term><term>Mâle</term><term>Os et tissu osseux</term><term>Ostéo-intégration</term><term>Propriétés de surface</term><term>Sujet âgé</term><term>Suède</term><term>Titane</term><term>Tomographie en microscopie électronique</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Suède</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Osseointegration, the direct contact between an implant surface and bone tissue, plays a critical role in interfacial stability and implant success. Analysis of interfacial zones at the micro- and nano-levels is essential to determine the extent of osseointegration. In this paper, a series of state-of-the-art microscopy techniques are used on laser-modified implants retrieved from humans. Partially laser-modified implants were retrieved after two and a half months' healing and processed for light and electron microscopy. Light microscopy showed osseointegration, with bone tissue growing both towards and away from the implant surface. Transmission electron microscopy revealed an intimate contact between mineralized bone and the laser-modified surface, including bone growth into the nano-structured oxide. This novel observation was verified by three-dimensional Z-contrast electron tomography, enabling visualization of an apatite layer, with different crystal direction compared with the apatite in the bone tissue, encompassing the nano-structured oxide. In conclusion, the present study demonstrates the nano-scale osseointegration and bonding between apatite and surface-textured titanium oxide. These observations provide novel data in human specimens on the ultrastructure of the titanium–bone interface.</p></div></front></TEI><affiliations><list><country><li>Suède</li></country></list><tree><country name="Suède"><noRegion><name sortKey="Palmquist, Anders" sort="Palmquist, Anders" uniqKey="Palmquist A" first="Anders" last="Palmquist">Anders Palmquist</name></noRegion><name sortKey="Br Nemark, Rickard" sort="Br Nemark, Rickard" uniqKey="Br Nemark R" first="Rickard" last="Br Nemark">Rickard Br Nemark</name><name sortKey="Grandfield, Kathryn" sort="Grandfield, Kathryn" uniqKey="Grandfield K" first="Kathryn" last="Grandfield">Kathryn Grandfield</name><name sortKey="Mattsson, Torsten" sort="Mattsson, Torsten" uniqKey="Mattsson T" first="Torsten" last="Mattsson">Torsten Mattsson</name><name sortKey="Norlindh, Birgitta" sort="Norlindh, Birgitta" uniqKey="Norlindh B" first="Birgitta" last="Norlindh">Birgitta Norlindh</name><name sortKey="Thomsen, Peter" sort="Thomsen, Peter" uniqKey="Thomsen P" first="Peter" last="Thomsen">Peter Thomsen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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